Nerofe causes ER stress to different type of cells
In Vitro assays have shown that Nerofe causes ER stress to cancer and endothelial cells, thus leading to cancer cell death and depletion of angiogenesis factors from serum, as seen in Phase Ia results. Because Immune cells express ST2 (Nerofe’s receptor), it is hypothesized
NerofeTM stimulates cancer cells attraction to APC and T cells and thereby inducing the death of cancer cells.
Recent FACS results have shown a significant increase in CD86 expressing cells in three types of malignant cells treated with NerofeTM.
CD86 is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells,
To date, 23 patients with advanced/metastatic solid tumors have been enrolled (3+3 protocol).
Toxicity: MTD has not been reached. Treatment was well-tolerated with no cumulative toxicity.
Pharmacokinetic analysis: AUC, Cmax and t½ were calculated and were dose-dependent and approximately linear.
Efficacy: 5 of 15 evaluable patients have been treated for at least 3 cycles and were considered