I. Anti-proliferative

Target lesion volume change following treatment

In 3 patients with elevated serum EGF levels, levels decreased to normal values (Remaining patients entered trial with normal EGF levels)


II. Anti-angiogenic

The Anti-angiogenic effect of Nerofe is dosage dependent.

Angiogensis factors drop during treatment

III. Induction of the Immune System

Nerofe dosage dependent activation of the immune system.


Selective biomarker for efficacy

Better treatment response of positive T1/ST2 tumors