I. Anti-proliferative

Target lesion volume change following treatment

In 3 patients with elevated serum EGF levels, levels decreased to normal values (Remaining patients entered trial with normal EGF levels)

Anti-proliferative-effect

II. Anti-angiogenic

The Anti-angiogenic effect of Nerofe is dosage dependent.

Angiogensis factors drop during treatment

III. Induction of the Immune System

Nerofe dosage dependent activation of the immune system.

Immuno-modulatory-effect

Selective biomarker for efficacy

Better treatment response of positive T1/ST2 tumors

Selective-biomarker-for-efficacy